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KCL in D5NS

Drug Description
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Potassium Chloride in 5% Dextrose and Sodium Chloride Injection, USP

in AVIVA Plastic Container

DRUG DESCRIPTION

Potassium Chloride in 5% Dextrose and Sodium Chloride Injection, USP is a sterile, nonpyrogenic solution for fluid and electrolyte replenishment and caloric supply in a single dose container for intravenous administration. It contains no antimicrobial agents. Composition, osmolarity, pH, ionic concentration and caloric content are shown in Table 1.

Table 1
 
Size (mL)
Composition (g/L)
*Osmolarity (mOsmol/L) (calc.)
pH
Ionic Concentration (mEq/L)
Caloric Content (kcal/L)
**Dextrose Hydrous, USP
Sodium Chloride, USP (NaCl)
Potassium Chloride, USP (KCl)
Sodium
Potassium
Chloride
Potassium Chloride in 5% Dextrose and 0.2% Sodium Chloride Injection, USP
mEq Potassium
10 mEq
1000
50
2
0.75
341
4.5(3.5to6.5)
34
10
44
170
20 mEq
1000
50
2
1.5
361
4.5(3.5to6.5)
34
20
54
170
10 mEq
500
30 mEq
1000
50
2
2.24
381
4.5(3.5to6.5)
34
30
64
170
40 mEq
1000
50
2
3
401
4.5(3.5to6.5)
34
40
74
170
Potassium Chloride in 5% Dextrose and 0.33% Sodium Chloride Injection, USP
mEq Potassium
20 mEq
1000
50
3.3
1.5
405
4.5(3.5to6.5)
56
20
76
170
10 mEq
500
30 mEq
1000
50
3.3
2.24
425
4.5(3.5to6.5)
56
30
86
170
40 mEq
1000
50
3.3
3
446
4.5(3.5to6.5)
56
40
96
170
Potassium Chloride in 5% Dextrose and 0.45% Sodium Chloride Injection, USP
mEq Potassium
10 mEq
1000
50
4.5
0.75
426
4.5(3.5to6.5)
77
10
87
170
20 mEq
1000
50
4.5
1.5
447
4.5(3.5to6.5)
77
20
97
170
10 mEq
500
30 mEq
1000
50
4.5
2.24
466
4.5(3.5to6.5)
77
30
107
170
40 mEq
1000
50
4.5
3
487
4.5(3.5to6.5)
77
40
117
170
Potassium Chloride in 5% Dextrose and 0.9% Sodium Chloride Injection, USP
mEq Potassium
20 mEq
1000
50
9
1.5
601
4.5(3.5to6.5)
154
20
174
170
40 mEq
1000
50
9
3
641
4.5(3.5to6.5)
154
40
194
170
*Normal physiologic osmolarity range is approximately 280 to 310 mOsmol/L.
Administration of substantially hypertonic solutions (≥600 mOsmol/L) may cause vein damage.

The flexible container is made with non-latex plastic materials specially designed for a wide range of parenteral drugs including those requiring delivery in containers made of polyolefins or polypropylene. For example, the AVIVA container system is compatible with and appropriate for use in the admixture and administration of paclitaxel. In addition, the AVIVA container system is compatible with and appropriate for use in the admixture and administration of all drugs deemed compatible with existing polyvinyl chloride container systems. The solution contact materials do not contain PVC, DEHP, or other plasticizers.

The suitability of the container materials has been established through biological evaluations, which have shown the container passes Class VI U.S. Pharmacopeia (USP) testing for plastic containers. These tests confirm the biological safety of the container system.

The flexible container is a closed system, and air is prefilled in the container to facilitate drainage. The container does not require entry of external air during administration.

The container has two ports: one is the administration outlet port for attachment of an intravenous administration set and the other port has a medication site for addition of supplemental medication (See Directions for Use). The primary function of the overwrap is to protect the container from the physical environment.

Brand Name: KCL in D5NS
Generic Name: Potassium Chloride in 5% Dextrose and Sodium Chloride Injection
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