- « Previous
- Clinical Pharmacology
- Next »
Toradol Oral
Clinical Pharmacology
Toradol Oral
| Type of Subjects | Total Clearance [in L/h/kg]3 | Terminal Half-life [in hours] | ||
| IM | ORAL | IM | ORAL | |
| Mean (range) |
Mean (range) |
Mean (range) |
Mean (range) |
|
| Normal Subjects IM (n=54) mean age=32, range=18–60 Oral (n=77) mean age=32, range=20–60 |
0.023 (0.010–0.046) |
0.025 (0.013–0.050) |
5.3 (3.5–9.2) |
5.3m (2.4–9.0) |
| Healthy Elderly Subjects IM (n=13), Oral (n=12) mean age=72, range=65–78 |
0.019 (0.013–0.034) |
0.024 (0.018–0.034) |
7.0 (4.7–8.6) |
6.1 (4.3–7.6) |
| Patients with Hepatic Dysfunction IM and Oral (n=7) mean age=51, range=43–64 |
0.029 (0.013–0.066) |
0.033 (0.019–0.051) |
5.4 (2.2–6.9) |
4.5 (1.6–7.6) |
| Patients with Renal Impairment IM (n=25), Oral (n=9) serum creatinine=1.9–5.0 mg/dL, mean age (IM)=54, range=35–71 mean age (Oral)=57, range=39–70 |
0.015 (0.005–0.043) |
0.016 (0.007–0.052) |
10.3 (5.9–19.2) | 10.8 (3.4–18.9) |
| Renal Dialysis Patients IM and Oral (n=9) mean age=40, range=27–63 |
0.016 (0.003–0.036) |
— | 13.6 (8.0–39.1) |
— |
| 1Estimated from 30 mg single
IM doses of ketorolac tromethamine 2Estimated from 10 mg single oral doses of ketorolac tromethamine 3Liters/hour/kilogram |
||||
IV Administration
In normal adult subjects (n=37), the total clearance of 30 mg IV-administered ketorolac tromethamine was 0.030 (0.017-0.051) L/h/kg. The terminal half-life was 5.6 (4.0-7.9) hours. (See Kinetics in Special Populations for use of IV dosing of ketorolac tromethamine in pediatric patients.)
Clinical studies
Adult Patients
In a postoperative study, where all patients received morphine by a PCA device, patients treated with ketorolac tromethamineIV as fixed intermittent boluses (e.g., 30 mg initial dose followed by 15 mg q3h), required significantly less morphine (26%) than the placebo group. Analgesia was significantly superior, at various postdosing pain assessment times, in the patients receiving ketorolac tromethamineIV plus PCA morphine as compared to patients receiving PCA-administered morphine alone.
Pediatric Patients
There are no data available to support the use of TORADOLORAL in pediatric patients.
Generic Name: Ketorolac Tromethamine
- « Previous
- Clinical Pharmacology
- Next »
Touch Your Way to Health
Hear from experts on different types of therapeutic massage, how to find a good therapist, and when you should avoid altogether. See more WebMD Videos »
Chronic Pain/Back Pain
Find tips and advances in treatment.
Toradol Oral
Health Resources
2008 Election & Health Care on WebMD. Get Informed.
Updated & New
RxList does not provide medical advice, diagnosis or treatment.