Refludan
OVERDOSE
In case of overdose (eg, suggested by excessively high aPTT values) the risk of bleeding is increased.
No specific antidote for REFLUDAN is available. If life-threatening bleeding occurs and excessive plasma levels of lep-irudin are suspected, the following steps should be followed:
- Immediately STOP REFLUDAN administration
- Determine aPTT and other coagulation levels as appropriate
- Determine hemoglobin and prepare for blood transfusion
- Follow the current guidelines for treating patients with shock
Individual clinical case reports and in vitro data suggest that either hemofiltration or hemodialysis (using high-flux dialysis membranes with a cutoff point of 50,000 daltons, eg, AN/69) may be useful in this situation.
In studies in pigs, the application of von Willebrand Factor (vWF, 66 IU/kg body weight) markedly reduced the bleeding time. The clinical significance of this data is unknown.
CONTRAINDICATIONS
REFLUDAN is contraindicated in patients with known hypersensitivity to hirudins or to any of the components in REFLUDAN [lepirudin (rDNA) for injection].
Generic Name: Lepirudin
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Refludan
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