Loracarbef is a synthetic b-lactam antibiotic of the carbacephem class for oral administration. Chemically, carbacephems differ from cephalosporin-class antibiotics in the dihydrothiazine ring where a methylene group has been substituted for a sulfur atom.

The chemical name for loracarbef is: (6R,7S)-7-[(R)-2-amino-2-phenylacetamido]-3-chloro-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2- carboxylic acid, monohydrate.

It is a white to off-white solid with a molecular weight of 367.8. The empirical formula is C₁₆H₁₆ClN₃O₄·H₂O.

Lorabid Pulvules and Lorabid for Oral Suspension are intended for oral administration only.

Each Pulvule contains loracarbef equivalent to 200 mg (0.57 mmol) or 400 mg (1.14 mmol) anhydrous loracarbef activity. They also contain cornstarch, dimethicone, F Dy & C blue No. 2, gelatin, iron oxides, magnesium stearate, titanium dioxide, and other inactive ingredients.

After reconstitution, each 5 ml of Lorabid for Oral Suspension contains loracarbef equivalent to 100 mg (0.286 mmol) or 200 mg (0.57 mmol) anhydrous loracarbef activity. The suspensions also contain cellulose, F Dy & C red No. 40, flavors, methylparaben, propylparaben, simethicone emulsion, sodium carboxymethylcellulose, sucrose, and xanthan gum.

Bookmark this page: