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Mavik

Drug Description
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MAVIK® (Abbott)
(Trandolapril Tablets)

Rx only

USE IN PREGNANCY

When used in pregnancy during the second and third trimesters,ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, MAVIK® should be discontinued as soon as possible. See WARNINGS, Fetal/Neonatal Morbidity and Mortality.

DRUG DESCRIPTION

Trandolapril is the ethyl ester prodrug of a nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor, trandolaprilat. Trandolapril is chemically described as (2S,3aR,7aS)-1-[(S)-N-[(S)-1-Carboxy-3-phenylpropyl]alanyl] hexahydro-2-indo-linecarboxylic acid, 1-ethyl ester. Its empirical formula is C24H34N2O5. M.W.=430.54 and Melting Point=125°C. Its structual formula is:

Trandolapril is a colorless, crystalline substance that is soluble (>100 mg/mL) in chloroform, dichloromethane, and methanol. MAVIK tablets contain 1 mg, 2 mg, or 4 mg of trandolapril for oral administration. Each tablet also contains corn starch, croscarmellose sodium, hydroxypropyl methylcellulose, iron oxide, lactose, povidone, sodium stearyl fumarate.

Brand Name: Mavik
Generic Name: Trandolapril
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