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Minocin Capsules

Clinical Pharmacology
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Clinical Pharmacology

Minocin Capsules

Susceptibility testing should be performed with tetracycline since it predicts susceptibility to minocycline. However, certain organisms (eg, some staphylococci and Acinetobacter species) may be more susceptible to minocycline and doxycycline than to tetracycline.

Dilution techniques

Quantitative methods are used to determine antimicrobial minimal inhibitory concentrations (MICs). These MICs provide estimates of the susceptibility of bacteria to antimicrobial compounds. The MICs should be determined using a standardized procedure. Standardized procedures are based on a dilution method (Ref1, Ref30 (broth or agar) or equivalent with standardized inoculum concentrations and standardized concentrations of tetracycline powder. The MIC values should be interpreted according to the following criteria:

For testing aerobic gram-negative microorganisms (Enterobacteriaceae), Acinetobacter species and Staphylococcus aureus:

MIC (µg/mL) Interpretation
≤ 4.0 Susceptible (S)
8.0 Intermediate (I)
≥ 16.0 Resistant (R)
For testing Haemophilus influenzae2 and Streptococcus pneumoniae3:
MIC (µg/mL) Interpretation
≤ 2.0 Susceptible (S)
4.0 Intermediate (I)
≥ 8.0 Resistant (R)
2 These interpretative standards are applicable only to broth microdilution susceptibility testing with Haemophilus influenzae using Haemophilus Test Medium.Ref1
3 These interpretative standards are applicable only to broth microdilution susceptibility testing using cation- adjusted Muller-Hinton broth with 2-5% lysed horse blood.1

For testing Neisseria gonorrhoeae4:

MIC (µg/mL) Interpretation
≤ 0.25 Susceptible (S)
0.5-1.0 Intermediate (I)
≥ 2.0 Resistant (R)
4 These interpretative standards are applicable only to agar dilution susceptibility testing using GC agar base and 1% defined growth supplements.Ref1

A report of "Susceptible" indicates that the pathogen is likely to be inhibited if the antimicrobial compound in the blood reaches the concentrations usually achievable. A report of "Intermediate" indicates that the result should be considered equivocal, and, if the microorganism is not fully susceptible to alternative, clinically feasible drugs, the test should be repeated. This category implies possible clinical applicability in body sites where the drug is physiologically concentrated or in situations where high dosage of drug can be used. This category also provides a buffer zone which prevents small uncontrolled technical factors from causing major discrepancies in interpretation. A report of "Resistant" indicates that the pathogen is not likely to be inhibited if the antimicrobial compound in the blood reaches the concentrations usually achievable; other therapy should be selected.

Standardized susceptibility test procedures require the use of laboratory control microorganisms to control the technical aspects of the laboratory procedures. Standard tetracycline powder should provide the following MIC values:

Microorganism MIC Range (µg/mL)
Escherichia coli ATCC 25922 0.5-2.0
Enterococcus faecalis ATC 29212 8.0-32.0
Staphylococcus aureus ATCC 29213 0.25-1.0
Haemophilus influenzae ATCC 49247 4.0-32.0
Streptococcus pneumoniae ATCC 49619 0.12-0.5
Neisseria gonorrhoeae ATCC 49226 0.25-1.0

Diffusion techniques
Brand Name: Minocin Capsules
Generic Name: Minocycline

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