Minocycline is not removed in significant quantities by hemodialysis or peritoneal dialysis. In one study, four patients received 200 mg oral doses 3 hours prior to hemodialysis, following flow rates of 100 to 200 mL/min there was no consistent difference between venous and arterial minocycline concentrations and no detectable minocycline was found in the dialysate. In another study, four patients were administered IP minocycline over 72 to 96 hours and achieved blood concentrations of 1.5 to 2 mcg/mL, over the following 12 hours drug free dialysate was used. No detectable minocycline was found to transfer from the blood to the dialysate.

In case of overdosage, discontinue medication, treat symptomatically and institute supportive measures.

This drug is contraindicated in persons who have shown hypersensitivity to any of the tetracyclines.

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