The physician should instruct patients:

• To follow carefully the physician's directions for taking this drug and not to alter these directions without authorization.
• To follow carefully the physician's directions for the periodic blood test (prothrombin time)re-quired to assure that the correct dose of the drug is being used.
• To discuss with the physician any other medication (prescription or nonprescription) to be used.
• To report to the physician any abnormal bleeding, such as blood in the urine, blood in the stool (a black, tarry appearance); bleeding from the gums or nose; patches of discoloration or bruises on the arms, legs, or toes; or excessive bleeding following minor cuts (eg, while shaving).
• To discuss with the physician any plan to become pregnant or to report any pregnancy promptly.

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