Vesiculation, ulceration, or necrosis may occur in highly sensitive subjects at the test site. Pain or pruritus at the test site may be relieved by topical glucocorticoid ointment or ice packs.

The administration of adrenal corticosteroids or immunosuppressive drugs may decrease the intensity of or prevent a tuberculin reaction. Tuberculin sensitivity may decrease or disappear temporarily as a result of febrile illness; measles and other exanthemas; live virus vaccination; sarcoidosis and miliary or pulmonary tuberculosis.

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