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OVERDOSE
There is no clinical experience with naloxone hydrochloride overdosage in humans.
In the mouse and rat, the intravenous LD50 is 150 ± 5 mg/kg and 109 ± 4 mg/kg, respectively. In acute subcutaneous toxicity studies in newborn rats, the LD50 (95% CL) is 260 (228-296) mg/kg. Subcutaneous injection of 100 mg/kg/day in rats for 3 weeks produced only transient salivation and partial ptosis following injection; no toxic effects were seen at 10 mg/kg/day for 3 weeks.
CONTRAINDICATIONS
Naloxone Hydrochloride Injection is contraindicated in patients known to be hypersensitive to it.
Generic Name: Naloxone
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