Ophthalmic Solution NEODECADRON† (Neomycin Sulfate-Dexamethasone Sodium Phosphate) is a topical corticosteroid-antibiotic solution for ophthalmic use.

Dexamethasone sodium phosphate is 9-fluoro-11ß, 17-dihydroxy-16α-methyl-21-(phosphonooxy)pregna-1, 4-diene-3, 20-dione disodium salt. Its empirical formula is C ₂₂ H ₂₈ FNa ₂ O ₈ P and its structural formula is:

Dexamethasone is a synthetic analog of naturally occurring glucocorticoids (hydrocortisone and cortisone).

Dexamethasone sodium phosphate is a water soluble, inorganic ester of dexamethasone. Its molecular weight is 516.41.

Neomycin sulfate, an antibiotic of the aminoglucoside group, is a mixture of the sulfate salts of neomycin, produced by the growth of Streptomyces fradiae Waksman (Fam. Stretomycetaceae). Neomycin is a complex typically containing 8-13% neomycin C, less than 0.2% neomycin A, and the rest, neomycin B. The empirical formula for both neomycin B and neomycin C is C ₂₃ H ₄₆ N ₆ O ₁₃ , and the molecular weight for each is 614.65. Neomycin A (also referred to as neamine) has an empirical formula of C ₁₂ H ₂₆ N ₄ O ₆ and a molecular weight of 322.36. The structural formulae for neomycin sulfate are:

Each milliliter of buffered Ophthalmic Solution NEODECADRON in the OCUMETER* ophthalmic dispenser contains: dexamethasone sodium phosphate equivalent to 1 mg (0.1%) dexamethasone phosphate, and neomycin sulfate equivalent to 3.5 mg neomycin base. Inactive ingredients: creatinine, sodium citrate, sodium borate, polysorbate 80, disodium edetate, hydrochloric acid to adjust pH to 6.6-7.2, and water for injection. Benzalkonium chloride 0.02% and sodium bisulfite 0.1% added as preservatives.

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