Table 4. Pharmacokinetics Parameters of Technetium Tc 99m Depreotide Radioactivity ^(a)

Subjects

Effective Half-Life

Vss

CL total

CL renal

ta (min)

tb (min)

tg (hour)

(L/kg)

(mL/min/kg)

(mL/min/kg)

(n=9)

4.3 ± 2.5

43.6 ± 11.5

22.4 ± 11.90

1.56 ± 0.85

2.12 ± 1.3

0.37 ± 0.22

Hepatic dysfunction (n=3)

4.0 ± 0.4

48.3 ± 7.5

18.0 ± 3.3

1.7 ± 0.4

2.45 ± 0.3

0.24 (n=1)

Renal dysfunction (n=3)

2.9 ± 0.7

52.0 ± 9.9

17.2 ± 8.2

1.49 ± 0.95

1.49 ± 0.72

Not evaluated

Lung cancer (n=2)^(b)

4.5,9.1

62,72

12.6,16.9

0.44,1.43

1.64,1.64

Not evaluated

^(a) Only radioactivity was measured. Data expressed as mean value ± SD (n) where "n"is the number of subjects or patients.

^(b) Only two lung cancer patients were studied;the calculated values for both patients are presented.