Olux-E (clobetasol propionate) Foam, an emulsion aerosol foam, contains the active ingredient clobetasol propionate, USP, a synthetic corticosteroid for topical dermatologic use. Clobetasol, an analog of prednisolone, has a high degree of glucocorticoid activity and a slight degree of mineralocorticoid activity.

Clobetasol propionate is 21-chloro-9-fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-propionate, with the empirical formula C₂₅H₃₂ClFO₅, and a molecular weight of 466.97. The following is the chemical structure:

Clobetasol Propionate, USP

Clobetasol propionate is a white to cream-colored crystalline powder, practically insoluble in water.

Each gram of Olux-E Foam contains 0.5 mg clobetasol propionate, USP. The foam also contains anhydrous citric acid USP, cetyl alcohol NF, cyclomethicone NF, isopropyl myristate NF, light mineral oil NF, polyoxyl 20 cetostearyl ether NF, potassium citrate monohydrate USP, propylene glycol USP, purified water USP, sorbitan monolaurate NF, white petrolatum USP, and phenoxyethanol NF as a preservative.

Olux-E Foam is dispensed from an aluminum can pressurized with a hydrocarbon (propane/butane) propellant.

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