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General - Papaverine Hydrochloride Injection, USP, should not be added to Lactated Ringers Injection, because precipitation would result.

Papaverine hydrochloride should be used with caution in patients with glaucoma. The medication should be discontinued if hepatic hypersensitivity with gastrointestinal symptoms, jaundice or eosinophilia becomes evident or if liver function test values become altered.

Usage in Pregnancy-Pregnancy Category C - No teratogenic effects were observed in rats when papaverine hydrochloride was administered subcutaneously as a single agent. It is not known whether papaverine can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Papaverine hydrochloride should be given to a pregnant woman only if clearly needed.

Nursing Mothers - It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when papaverine hydrochloride is administered to a nursing woman.

Usage in Children - Safety and effectiveness in children have not been established.

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