Approximately 50-60% of aminosalicylic acid is protein bound; binding is reported to be reduced 50% in kwashiorkor.

Microbiology: The aminosalicylic acid MIC for M. tuberculosis in 7H11 agar was less than 1.0 µg/mL for nine strains including three multidrug resistant strains, but 4 and 8 µg/mL for two other multidrug resistant strains. The 90% inhibition in 7H12 broth (Bactec) showed little dose response but was interpreted as being less than or equal to 0.12-0.25 µg/mL for eight strains of which three were multi-resistant, 0.50 µg/mL for one resistant strain, questionable for four nonresistant strains and greater than 1 µg/mL for one non-resistant and three resistant strains. Aminosalicylic acid is not active in vitro against M. avium.

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