There is limited experience with overdosage. In the clinical studies, a few patients accidentally received a dose greater than that prescribed. There were no instances in which a participant in the monotherapy or combination therapy trials received more than 10.5 times the intended dose of PEG-Intron. The maximum dose received by any patient was 3.45 mg/kg weekly over a period of approximately 12 weeks. The maximum known overdosage of REBETOL was an intentional ingestion of 10 g (fifty 200-mg capsules). There were no serious reactions attributed to these overdosages. In cases of overdosing, symptomatic treatment and close observation of the patient are recommended.

· hypersensitivity to PEG-Intron or any other component of the product
· autoimmune hepatitis
· hepatic decompensation (Child-Pugh score >6 [class B and C]) in cirrhotic CHC patients before during treatment.

· patients with hypersensitivity to ribavirin or any other component of the product
· women who are pregnant
· men whose female partners are pregnant
· patients with hemoglobinopathies (e.g., thalassemia major, sickle-cell anemia)
· patients with creatinine clearance < 50 mL/min

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