CAUTION: Fatalities due to severe hypotension, hypoglycemia, acute pancreatitis and cardiac arrhythmias have been reported in patients treated with pentamidine isethionate, both by the I.M. and I.V. routes. The administration of the drug should, therefore, be limited to the patients in whom Pneumocystis carinii has been demonstrated.

Of 424 patients treated with pentamidine isethionate, 244 (57.5%) developed some adverse reaction. Most of the patients had the acquired immunodeficiency syndrome (AIDS). In the following table, ''Severe'' refers to life- threatening reactions or reactions that required immediate corrective measures and led to discontinuation of pentamidine isethionate.

* Patient total may not equal sum of reactions, since some patients had more than one reaction.
** Each of the following moderate adverse reactions was reported in one patient : Hypocalcemia, abnormal ST segment of electrocardiogram, bronchospasm, diarrhea, and hyperglycemia.