Pentamidine Isethionate For Injection is indicated for the treatment of pneumonia due to Pneumocystis carinii.

Pentamidine isethionate should be administered I.M. or I.V. only. The recommended regimen for adults and children is 4 mg/ kg once a day for 14 days. The benefits and risks of therapy with pentamidine isethionate for more than 14 days are not well defined.

Intramuscular Injection

The contents of one vial (300 mg) should be dissolved in 3 mL of Sterile Water for Injection. The calculated daily dose should then be withdrawn and administered by deep I.M. injection.

Intravenous Injection

The contents of one vial should first be dissolved in 3 to 5 mL of Sterile Water for Injection or Dextrose Injection 5%. The calculated dose of pentamidine isethionate should then be withdrawn and diluted further in 50 to 250 mL of Dextrose Injection 5%. The diluted I.V. solutions containing pentamidine isethionate should be infused over a period of 60 minutes.

Aseptic technique should be employed in preparation of all solutions. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration. Intravenous infusion solutions of pentamidine isethionate at 1 mg and 2.5 mg/mL prepared in Dextrose Injection 5% are stable at room temperature for up to 24 hours.

Pentamidine Isethionate For Injection is a sterile, lyophilized powder supplied in a single-dose, fliptop vial containing 300 mg of pentamidine isethionate packaged in individual cartons (List 4548).

Store the dry product at controlled room temperature 15° to 30° C (59° to 86° F). Protect the dry product and reconstituted solution from light. Retain in carton until time of use.

Discard unused portions.

Caution: Federal (USA) law prohibits dispensing without prescription.

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