Manifestations: Clinical experience of overdosage with this oral medication has been insufficient to define the signs of this condition.

Treatment: Oxygen, intravenous fluids, vasopressors, and other supportive measures should be employed as indicated. Assisted or controlled ventilation should also be considered. For respiratory depression due to overdosage or unusual sensitivity to pentazocine, parenteral naloxone is a specific and effective antagonist.

TALWIN® Nx is intended for oral use only. Severe, potentially lethal, reactions may result from misuse of TALWIN® Nx by injection either alone or in combination with other substances. (See DRUG ABUSE AND DEPENDENCE section.)

TALWIN Nx should not be administered to patients who are hypersensitive to either pentazocine or naloxone.

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