The most frequent adverse reactions to Brompheniramine Maleate, Dextromethorphan HBr and Phenylpropanolamine HCl Liquid include sedation, dryness of the mouth, nose and throat, thickening of bronchial secretions, and dizziness. Other adverse reactions may include:

• DERMATOLOGIC - Urticaria, drug rash photosensitivity and pruritus.
• CARDIOVASCULAR SYSTEM - Hypotension, hypertension, cardiac arrhythmias.
• CENTRAL NERVOUS SYSTEM - Disturbed coordination, tremor, irritability, insomnia, visual disturbances, weakness, nervousness, convulsions, headache, euphoria and dysphoria.
• G.U. SYSTEM - Urinary frequency, difficult urination.
• G.I SYSTEM - Epigastric discomfort, anorexia, nausea, vomiting, diarrhea or constipation.
• RESPIRATORY SYSTEM - Tightness of chest and wheezing, shortness of breath.
• HEMATOLOGIC SYSTEM - Hemolytic anemia, thrombocytopenia agranulocytosis.

Antihistamines have additive effects with alcohol and other CNS depressants (hypnotics, sedatives, tranquilizers, antianxiety agents, etc.). MAO inhibitors prolong and intensify the anticholemic (drying) effects of antihistamines. MAO inhibitors may enhance the effects of phenylpropanolamine. Sympathomimetics may reduce the effects of antihypertensive drugs.

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