Overdosage of estrogen may cause nausea and vomiting, breast tenderness, abdominal pain, drowsiness/fatigue; and withdrawal bleeding may occur in females. Treatment of overdose consists of discontinuation of Premarin therapy with institution of appropriate symptomatic care.

Premarin Vaginal Cream therapy should not be used in women with any of the following conditions:

1. Undiagnosed abnormal genital bleeding.
2. Known, suspected, or history of cancer of the breast.
3. Known or suspected estrogen-dependent neoplasia.
4. Active deep vein thrombosis, pulmonary embolism or a history of these conditions.
5. Active or recent (within past year) arterial thromboembolic disease (for example, stroke, myocardial infarction).
6. Liver dysfunction or disease.
7. Known hypersensitivity to any of the ingredients in Premarin Vaginal Cream.
8. Known or suspected pregnancy.

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