PRINZIDE^* (Lisinopril-Hydrochlorothiazide) combines an angiotensin converting enzyme inhibitor, lisinopril, and a diuretic, hydrochlorothiazide.

Lisinopril, a synthetic peptide derivative, is an oral long-acting angiotensin converting enzyme inhibitor. It is chemically described as (S)-1-[N²-(1-carboxy-3-phenylpropyl)-L-lysyl]-L-proline dihydrate. Its empirical formula is C₂₁H₃₁N₃O₅· 2H₂O and its structural formula is:

Lisinopril is a white to off-white, crystalline powder, with a molecular weight of 441.52. It is soluble in water, sparingly soluble in methanol, and practically insoluble in ethanol.

Hydrochlorothiazide is 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide. Its empirical formula is C₇H₈ClN₃O₄S₂ and its structural formula is:

Hydrochlorothiazide is a white, or practically white, crystalline powder with a molecular weight of 297.73, which is slightly soluble in water, but freely soluble in sodium hydroxide solution.

PRINZIDE is available for oral use in three tablet combinations of lisinopril with hydrochlorothiazide: PRINZIDE 10-12.5, containing 10 mg lisinopril and 12.5 mg hydrochlorothiazide, PRINZIDE 20-12.5, containing 20 mg lisinopril and 12.5 mg hydrochlorothiazide and PRINZIDE 20-25, containing 20 mg lisinopril and 25 mg hydrochlorothiazide.

Inactive ingredients are calcium phosphate, magnesium stearate, mannitol, and starch. PRINZIDE 10-12.5 also contains FD&C Blue #2 aluminum lake. PRINZIDE 20-12.5 and PRINZIDE 20-25 also contain iron oxide.

* Registered trademark of MERCK & CO., Inc. COPYRIGHT © 1989, 1992, 2005 MERCK & CO., Inc. All rights reserved

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