Promethazine

Nervous System: Sedation, sleepiness, occasional blurred vision, dryness of mouth, dizziness; rarely: confusion, disorientation, and extrapyramidal symptoms such as oculogyric crisis, torticollis, and tongue protrusion (usually in association with parenteral injection or excessive dosage).

Cardiovascular: Increased or decreased blood pressure.

Dermatologic: Rash; rarely: photosensitivity.

Hematologic: Rarely: leukopenia, thrombocytopenia; agranulocytosis (1 case).

Gastrointestinal: Nausea and vomiting.

Phenylephrine

Nervous System: Restlessness, anxiety, nervousness, and dizziness.

Cardiovascular: Hypertension (see WARNINGS).

Other: Precordial pain, respiratory distress, tremor, and weakness.

Promethazine

The sedative action of promethazine is additive to the sedative effects of other central nervous system depressants, including alcohol, narcotic analgesics, sedatives, hypnotics, tricyclic antidepressants, and tranquilizers; therefore, these agents should be avoided or administered in reduced dosage to patients receiving promethazine.

Phenylephrine

Drug: Phenylephrine with prior administration of monoamine oxidase inhibitors (MAOI).

Effect: Cardiac pressor response potentiated. May cause acute hypertensive crisis.

Drug: Phenylephrine with tricyclic antidepressants.

Effect: Pressor response increased.

Drug: Phenylephrine with ergot alkaloids.

Effect: Excessive rise in blood pressure.

Drug: Phenylephrine with bronchodilator sympathomimetic agents and with epinephrine or other sympathomimetics.

Effect: Tachycardia or other arrhythmias may occur.

Drug: Phenylephrine with atropine sulfate.

Effect: Reflex bradycardia blocked; pressor response enhanced.

Drug: Phenylephrine with prior administration of propranolol or other b- adrenergic blockers.

Effect: Cardiostimulating effects blocked.

Drug: Phenylephrine with prior administration of phentolamine or other a- adrenergic blockers.

Effect: Pressor response decreased.

Drug: Phenylephrine with diet preparations, such as amphetamines or phenylpropanolamine.

Effect: Synergistic adrenergic response.

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