Patients who receive Quadramet should be advised that for several hours following administration, radioactivity will be present in excreted urine. To help protect themselves and others in their environment, precautions need to be taken for 12 hours following administration. Whenever possible, a toilet should be used, rather than a urinal, and the toilet should be flushed several times after each use. Spilled urine should be cleaned up completely and patients should wash their hands thoroughly. If blood or urine gets onto clothing, the clothing should be washed separately, or stored for 1-2 weeks to allow for decay of the Sm-153.

Some patients have reported a transient increase in bone pain shortly after injection (flare reaction). This is usually mild and self-limiting and occurs within 72 hours of injection. Such reactions are usually responsive to analgesics.

Patients who respond to Quadramet might begin to notice the onset of pain relief one week after Quadramet. Maximal pain relief generally occurs at 3-4 weeks after injection of Quadramet. Patients who experience a reduction in pain may be encouraged to decrease their use of opioid analgesics.

Please also see the WARNINGS and PRECAUTIONS sections.

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