The in vitro human plasma protein binding of rimantadine is about 40% over typical plasma concentrations. Albumin is the major binding protein.

REFERENCES

1. Belshe, R.B., Burk, B., Newman, F., Cerruti, R.L. and Sim, I.S. (1989) J. Infect. Dis. 159, 430-435.
2. Sim, I.S., Cerruti, R.L. and Connell, E.V., (1989) J. Resp. Dis. (Suppl.), S46-S51.
3. Hayden, F.G., Belshe, R.B., Clover, R.D. et al (1989) N.Engl. J. Med. 321 (25), 1696-1702.

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