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Rondec

Clinical Pharmacology
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CLINICAL PHARMACOLOGY

Rondec

Antihistaminic and decongestant actions.

Carbinoxamine maleate possesses H1 antihistaminic activity and mild anticholinergic and sedative effects. Serum half life for carbinoxamine is estimated to be 10 to 20 hours. Virtually no intact drug is excreted in the urine.

Pseudoephedrine hydrochloride is an oral sympathomimetic amine that acts as a decongestant to respiratory tract mucous membranes. While its vasoconotrictor action is similar to that of ephedrine, pseudoephedrine has less pressor effect in normotensive adults. Serum half life for pseudoephedrine is 6 to 8 hours. Acidic urine is associated with faster elimination of the drug. About one half of the administered dose is excreted in the urine.



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