DISALCID is indicated for relief of the signs and symptoms of rheumatoid arthritis, osteoarthritis and related rheumatic disorders.

Adults

The usual dosage is 3000 mg daily, given in divided doses as follows: 1) two doses of two 750 mg tablets: 2) two doses of three 500 mg tablets/capsules; or 3) three doses of two 500 mg tablets/capsules. Some patients, e.g., the elderly, may require a lower dosage to achieve therapeutic blood concentrations and to avoid the more common side effects such as auditory.

Alleviation of symptoms is gradual, and full benefit may not be evident for 3 to 4 days, when plasma salicylate levels have achieved steady state. There is no evidence for development of tissue tolerance (tachyphylaxis) but salicylate therapy may induce increased activity of metabolizing liver enzymes, causing a greater rate of salicyluric acid production and excretion, with a resultant increase in dosage requirement for maintenance of therapeutic serum salicylate levels.

Children

Dosage recommendations and indications for DISALCID use in children have not been established.

Each DISALCID 500 mg aqua/white capsule printed with Disalcid/3M is available in:
      Bottles of 100 (NDC #0089-0148-10)

Each DISALCID 500 mg aqua, film coated, round, bisected tablet embossed with DISALCID on one side and 3M on the other side is available in:
      Bottles of 100 (NDC #0089-0149-10)
      Bottles of 500 (NDC #0089-0149-50)

Each DISALCID 750 mg aqua, film coated, capsule shaped, bisected tablet embossed with DISALCID 750 on one side and 3M on the other side is available in:
      Bottles of 100 (NDC #0089-0151-10)
      Bottles of 500 (NDC #0089-0151-50)

Store at controlled room temperature 15°-30°C (59°-86°F).
Rx only

JUNE 1998

3M Pharmaceuticals
Northridge, CA 91324