Sermorelin acetate is the acetate salt of an amidated synthetic 29-amino acid peptide (GRF 1-29 NH ₂ ) that corresponds to the amino-terminal segment of the naturally occurring human growth hormone-releasing hormone (GHRH or GRF) consisting of 44 amino acid residues.

The free base of sermorelin has the empirical formula C ₁₄₉ H ₂₄₆ N ₄₄ O ₄₂ S and a molecular weight of 3,358 daltons.

Geref® is a sterile, non-pyrogenic, lyophilized powder intended for subcutaneous injection after reconstitution with Sodium Chloride Injection, USP. The reconstituted solution has a pH of 5.0 to 5.5.

Geref® is available in vials. The quantitative composition per vial is:

0.5 mg vial:  Each vial contains 0.5 mg sermorelin (as the acetate) and 5 mg mannitol.
                   The pH is adjusted with dibasic sodium phosphate and
                   monobasic sodium phosphate buffer.

1.0 mg vial:  Each vial contains 1.0 mg sermorelin (as the acetate) and 5 mg mannitol.
                   The pH is adjusted with dibasic sodium phosphate and
                   monobasic sodium phosphate buffer.

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