Serostim^Ã? LQ [somatropin (rDNA origin) injection] is a human growth hormone (hGH) produced by recombinant DNA technology. Serostim^Ã? has 191 amino acid residues and a molecular weight of 22,125 daltons. Its amino acid sequence and structure are identical to the dominant form of human pituitary GH. Serostim^Ã? is produced by a mammalian cell line (mouse C127) that has been modified by the addition of the hGH gene. Serostim^Ã? is secreted directly through the cell membrane into the cell-culture medium for collection and purification.

Serostim^Ã? LQ is a highly purified preparation. Biological potency is determined by measuring the increase in the body weight induced in hypophysectomized rats. Serostim^Ã? LQ may contain not more than 18% growth hormone (GH)-related proteins at expiration.

Serostim^Ã? LQ is available in 6 mg cartridges for single dose administration. Each 6 mg cartridge contains 0.5 mL of 8.16 mg (approximately 18 IU) somatropin, 1.02 mg Poloxamer 188, 40.8 mg sucrose, 1.31 mg citric acid and Water for Injection USP q.s. to 0.68g. The pH is adjusted with sodium hydroxide to give a pH of 5.85 + 0.1.

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