CloseClose
Find a Drug
Advanced Search

Professional

Meridia

Clinical Pharmacology
font size

Clinical Pharmacology

Meridia

The effect of sibutramine 15 mg once daily on measures of 24-hour blood pressure was evaluated in a 12-week placebo-controlled study. Twenty-six male and female, primarily Caucasian individuals with an average BMI of 34 kg/m2 and an average age of 39 years underwent 24-hour ambulatory blood pressure monitoring (ABPM). The mean changes from baseline to Week 12 in various measures of ABPM are shown in the following table.


Parameter mm Hg Systolic Diastolic
Placebo Sibutramine Placebo Sibutramine
  n=12 15 mg
n=14		 20 mg
n=16		   15 mg
n=12		 20 mg
n=16
Daytime 0.2 3.9 4.4 0.5 5.0 5.7
Nighttime -0.3 4.1 6.4 -1.0 4.3 5.4
Early am -0.9 9.4 5.3 -3.0 6.7 5.8
24-hour mean -0.1 4.0 4.7 0.1 5.0 5.6

Normal diurnal variation of blood pressure was maintained.

Brand Name: Meridia
Generic Name: Sibutramine Hydrochloride Monohydrate
Bookmark this page:

Privacy Policy

Women's Health

Find out what women really need.

WebMD Symptom Checker - Start Here Ringworm Slideshow: Watch and Learn
WebMD Resources

Breakfast is BestBreakfast is Best
Whether you are trying to lose weight or maintain your current weight, breakfast should be an important part of your strategy See more WebMD Videos »