SIMCOR tablets contain niacin extended-release (NIASPAN) and simvastatin in combination. Simvastatin, an inhibitor of HMG-CoA reductase, and niacin are both lipid-altering agents.

Niacin Extended-Release

Niacin is nicotinic acid, or 3-pyridinecarboxylic acid. Niacin is a white, nonhygroscopic crystalline powder that is very soluble in water, boiling ethanol, and propylene glycol. It is insoluble in ethyl ether. The empirical formula of niacin is C₆H₅NO₂ and its molecular weight is 123.11. Niacin has the following structural formula:

Simvastatin

Simvastatin is butanoic acid, 2,2-dimethyl-,1,2,3,7,8,8a-hexahydro-3-7-dimethyl-8-[2-(tetrahydro-4- hydroxy-6-oxo-2H-pyran-2-yl)-ethyl]-1-naphthalenyl ester, [1S-[1α,3α,7β,8β(2S*4S*),-8aβ]]. Simvastatin is a white to off-white, nonhygroscopic, crystalline powder that is practically insoluble in water and freely soluble in chloroform, methanol, and ethanol. The empirical formula of simvastatin is C₂₅H₃₈O₅ and its molecular weight is 418.57. Simvastatin has the following structural formula:

SIMCOR is available for oral administration as tablets containing 500 mg of extended-release niacin (NIASPAN) and 20 mg simvastatin (SIMCOR 500/20), 750 mg of extended-release niacin (NIASPAN) and 20 mg simvastatin (SIMCOR 750/20), and 1000 mg of extended-release niacin (NIASPAN) and 20 mg simvastatin (SIMCOR 1000/20). Each tablet contains the following inactive ingredients: hypromellose, povidone, stearic acid, polyethylene glycol, butylated hydroxyanisole, a blue Opadry® color coat (FD&C Blue #2, hypromellose, lactose monohydrate, titanium dioxide, triacetin), and a clear Opadry® coat (hypromellose, polyethylene glycol).

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