Intentional or accidental overdosage with BETAPACE® (sotalolhydro chloride) has rarely resulted in death.

Symptoms and Treatment of

The most common signs to be expected are bradycardia, congestive heart failure, hypotension, bronchospasm and hypoglycemia. In cases of massive intentional overdosage (2-16 grams) of BETAPACE® the following clinical findings were seen: hypotension, bradycardia, cardiac asystole, prolong ation of QT interval, torsade de pointes, ventricular tachycardia, and premature ventricular complexes. If overdosage occurs, therapy with BETAPACE® should be discontinued and the patient observed closely. Because of the lack of protein binding, hemodialysis is useful for reducing sotalolplasma concentrations. Patients should be carefully observed until QT intervals are normalized and the heart rate returns to levels >50 bpm. In addition, if required, the following therapeutic measures are suggested: