Bacterial and fungal corneal ulcers have developed during treatment with sulfonamide ophthalmic preparations.

The most frequently reported reactions are local irritation, stinging and burning. Less commonly reported reactions include non-specific conjunctivitis, conjunctival hyperemia, secondary infections and allergic reactions.

Fatalities have occurred, although rarely, due to severe reactions to sulfonamides including Stevens-Johnson syndrome, toxic epiderrnal necrolysis. fulminant hepatic necrosis, agranutocytosis, aplastic anemia, and other blood dyscrasias (see WARNINGS).

Sulfacetamide preparations are incompatible with silver preparations.

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