Supprelin LA (histrelin acetate) subcutaneous implant contains a synthetic nonapeptide analog of the naturally occurring gonadotropin releasing hormone (GnRH) that possesses a greater potency than the natural sequence hormone. The chemical name of histrelin acetate is:

L-Pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-N-benzyl-D-histidyl-L-leucyl-L-arginyl-L-proline N-ethylamide, acetate salt.

The molecular formula for histrelin acetate is C66H86N18O12 x 2 CH3COOH and its molecular weight is 1443.70 (or 1323.52 as free base). Histrelin is also chemically described as 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-Nt-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide diacetate. The chemical structure of the free base (histrelin) is represented below in Figure 1.

Figure 1. Structure of histrelin

Figure 2. Histrelin Implant diagram (not to scale)

The drug core also contains the inactive ingredient stearic acid NF. The hydrogel reservoir is a cartridge composed of 2-hydroxyethyl methacrylate, 2-hydroxypropyl methacrylate, trimethylolpropane trimethacrylate, benzoin methyl ether, Perkadox-16, and Triton X-100. Each hydrated implant is packaged in a glass vial containing 2 mL of 1.8% sodium chloride, sterile solution, so that it is primed for immediate release of the drug upon insertion. The 3.5 mL Type I clear glass vial with the implant is closed with a pre-treated grey Teflon coated stopper and sealed with an aluminum crimp seal.

A single use sterile insertion tool (Trocar) is to be used with Supprelin LA. The insertion tool is enclosed in a sterile bag as part of the implantation kit.

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