Figure 2: Mean (SD) steady state serum testosterone concentrations during nightly application of Androderm 2.5 mg systems in 29 hypogonadal male patients, 27 patients used 2 systems nightly and 2 patients used 3 systems nightly. Area between the dashed lines shows the 95% confidence interval for the circadian variation observed in healthy young men.¹ System application (t=0) at approximately 10 PM.

Table 1: Steady-state serum testosterone pharmacokinetic parameters in hypogonadal men measured during continuous Androderm (testosterone transdermal system) treatment.

C_max = maximum serum concentration
C_avg = average serum concentration (AUC/24 hr)
C_min = minimum serum concentration
T_max = time of maximum serum concentration
T ½ = elimination half-life
CL = clearance

In a group of 34 hypogonadal men, application of two Androderm 2.5 mg systems to the abdomen, back, thighs, or upper arms resulted in average testosterone absorption of 4 to 5 mg over 24 hours. The serum testosterone concentration profiles during application were similar for these sites (Table 2). Applications to the chest and shins resulted in greater inter-individual variability and average 24 hour absorption of 3 to 4 mg.

Table 2: Mean serum testosterone concentrations (ng/dL) measured during single-dose applications of two Androderm 2.5 mg systems applied at night to different sites in 34 hypogonadal men

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