· Tramadol Hydrochloride may impair mental or physical abilities required for the performance of potentially hazardous tasks such as driving a car or operating machinery.

· Tramadol Hydrochloride should not be taken with alcohol containing beverages.

· Tramadol Hydrochloride should be used with caution when taking medications such as tranquilizers, hypnotics or other opiate containing analgesics.

· Female patients should be instructed to inform the physician if they are pregnant, think they might become pregnant, or are trying to become pregnant (see PRECAUTIONS, Labor and Delivery ).

· The patient should understand the single-dose and 24-hour dose limit and the time interval between doses, since exceeding these recommendations can result in respiratory depression, seizures and death.

· To open the blister pack, peel back the foil on the blister. Do not push tablet through the foil. Remove the tablet and place it in the mouth, where it will dissolve in seconds and then be swallowed with the saliva.

· Tablet may be taken with or without water.

· Do NOT chew, break, or split the tablet.

· Phenylketonurics: Tramadol Hydrochloride contains phenylalanine.

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