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Rezulin

Clinical Pharmacology
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Clinical Pharmacology

Rezulin

226

231

220

Adjusted Mean Change From Baseline

-31

-38

-56

Adjusted Mean Difference

-54"

-61**

-79**

From Glyburide HbA 1C ( %) Mean Baseline

9.5

9.7

9.5

Adjusted Mean Change From Baseline

-0.7

-0.9

-1.8

Adjusted Mean Difference

-1.6"

-1.8**

-2.7*

From Glyburide Insulin (uU/mL) Mean Baseline

28.2

24.9

26.4

Adjusted Mean Change From Baseline

-3.8

-5.9

-6.1

Adjusted Mean Difference

-2.4

-4.4'

-4.6"

From Glyburide * p <0.05 compared to continuation of glyburide monotherapy.

** p <0. 0001 compared to continuation of glyburide monotherapy.


TABLE 3.

Combination Therapy With Glyburide: Percent of Patients

Achieving Glycemic Control at End of Study (1 yr)
Rezulin (mg)

0

200

400

600
Glyburide (mg)

12

12

12

12
HbA, 1C %
<7%

1

22

21

41
<8%

10
Brand Name: Rezulin
Generic Name: Troglitazone (removed from the US market 3/21/00)
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