Rezulin should be taken with meals. If the dose is missed at the usual meal, it may be taken at the next meal. If the dose is missed on one day, the dose should not be doubled the following day.

It is important to adhere to dietary instructions and to regularly have blood glucose and glycosylated hemoglobin tested. During periods of stress such as fever, trauma, glucose and glycosyin jection, or surgery, insulin requirements may change and patients should seek the advice of their physician. Patients who develop nausea, vomiting, abdominal pain. fatigue, anorexia, dark urine or other symptoms suggestive of hepatic dysfunction or jaundice should immediately report these signs or symptoms to their physician.

When using combination therapy with insulin or oral hypoglycemic agents. the risks of hypoglycemia, its symptoms and treatment, and conditions that predispose to its development should be explained to patients and their family members.

Use of Rezulin can cause resumption of ovulation in women taking oral contraceptives and in patients with polycystic ovary disease. Therefore, a higher dose of an oral contraceptive or an alternative method of contraception should be considered.

Rezulin may affect other medications used in diabetic patients. Patients started on Rezulin should ask their physician to review their other medications to make sure that they are not affected by Rezulin.

See also WARNINGS, CONTRAINDICATIONS, PRECAUTIONS.

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