Physicians are advised to discuss the following with patients prior to treatment with VELCADE:

Ability to Drive or Operate Machinery or Impairment of Mental Ability: VELCADE may cause fatigue, dizziness, syncope, orthostatic/postural hypotension. Patients should be advised not to drive or operate machinery if they experience any of these symptoms.

Dehydration/Hypotension: Since patients receiving VELCADE therapy may experience vomiting and/or diarrhea, patients should be advised regarding appropriate measures to avoid dehydration. Patients should be instructed to seek medical advice if they experience symptoms of dizziness, light headedness or fainting spells.

Pregnancy/Nursing: Patients should be advised to use effective contraceptive measures to prevent pregnancy during treatment with VELCADE. If a patient becomes pregnant during treatment she should be instructed to inform her physician immediately. Patients should also be advised not to take VELCADE treatment while pregnant or breast-feeding. If a patient wishes to restart breastfeeding after treatment, she should be advised to discuss the appropriate timing with her physician.

Concomitant Medications: Patients should be advised to speak with their physician about any other medication they are currently taking.

Diabetic Patients: Patients should be advised to check their blood sugar frequently if using an oral antidiabetic medication and notify their physician of any changes in blood sugar level.

Peripheral Neuropathy: Patients should be advised to contact their physician if they experience new or worsening symptoms of peripheral neuropathy such as tingling, numbness, pain, a burning feeling in the feet or hands, or weakness in the arms or legs.

Other: Patients should be instructed to contact their physician if they develop a rash, experience shortness of breath, cough, or swelling of the feet, ankles, or legs, convulsion, persistent headache, reduced eyesight, an increase in blood pressure or blurred vision.

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