VERELAN^® PM (verapamil hydrochloride) is a calcium ion influx inhibitor (slow channel blocker or calcium ion antagonist). VERELAN PM is available for oral administration as a 100 mg hard gelatin capsule (white opaque cap/amethyst body), a 200 mg hard gelatin capsule (amethyst opaque cap/amethyst body), and as a 300 mg hard gelatin capsule (lavender opaque cap/amethyst body). Verapamil is administered as a racemic mixture of the R and S enantiomers.

The structural formulae of the verapamil HCl enantiomers are:

C₂₇H₃₈N₂O_4· HCl     M.W. = 491.07

Chemical name: Benzeneacetonitrile, a -[3-[[2-(3,4-dimethoxyphenyl) ethyl] methylamino ] propyl ] -3,4-dimethoxy-a -(l-methylethyl)-, monohydrochloride,(±)-.

Verapamil HCl is an almost white, crystalline powder, practically free of odor, with a bitter taste. It is soluble in water, chloroform and methanol. Verapamil HCl is not structurally related to other cardioactive drugs.

In addition to verapamil HCl the VERELAN PM capsule contains the following inactive ingredients: D&C Red # 28, FD& C Blue #1, FD &C red #40, furmaric acid, gelatin,povidone, shellac, silicon dioxide, sodium lauryl sulfate, starch, sugar spheres, talc, and titanium dioxide.

Bookmark this page: