Velban
DRUG DESCRIPTION
| WARNING Caution - This preparation should be administered by individuals experienced in the administration of vinblastine sulfate. It is extremely important that the needle be properly positioned in the vein before this product is injected. If leakage into surrounding tissue should occur during intravenous administration of vinblastine sulfate, it may cause considerable irritation. The injection should be discontinued immediately, and any remaining portion of the dose should then be introduced into another vein. Local injection of hyaluronidase and the application of moderate heat to the area of leakage help disperse the drug and are thought to minimize discomfort and the possibility of cellulitis. FATAL IF GIVEN INTRATHECALLY. FOR INTRAVENOUS USE ONLY. See WARNINGS Section for the treatment of patients given intrathecal vinblastine. |
Vinblastine Sulfate for Injection USP is the salt of an alkaloid extracted from Vinca rosea Linn., a common flowering herb known as the periwinkle (more properly known as Catharanthus roseus G. Don). Previously, the generic name was vincaleukoblastine, abbreviated VLB. It is a stathmokinetic oncolytic agent. When treated in vitro with this preparation, growing cells are arrested in metaphase.
Chemical and physical evidence indicates that vinblastine sulfate has the molecular formula C46H58O9N4 H2SO4 and that it is a dimeric alkaloid containing both indole and dihydroindole moieties. It has a molecular weight of 909.06.
Vials of Vinblastine Sulfate for Injection USP contain 10 mg of the drug, in the form of a lyophilized powder, without excipients. When Bacteriostatic Sodium Chloride Injection USP is added prior to injection, the pH of the resulting solution lies in the range of 3.5 to 5.
Generic Name: Vinblastine Sulfate
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Velban
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