Oncovin
DRUG DESCRIPTION
|
WARNINGS Caution- This preparation should be administered by individuals experienced in the administration of vincristine sulfate injection. It is extremely important that the intravenous needle or catheter be properly positioned before any vincristine is injected. Leakage into surrounding tissues during intravenous administration of vincristine sulfate injection may cause considerable irritation. If extravasation occurs, the injection should be discontinued immediately, and any remaining portion of the dose should then be introduced into another vein. Local injection of hyaluronidase and the application of moderate heat to the area of leakage help disperse the drug and are thought to minimize discomfort and the possibility of cellulitis. FATAL IF GIVEN INTRATHECALLY. FOR INTRAVENOUS USE ONLY. See WARNINGS section for the treatment of patients given intrathecal vincristine sulfate injection. |
Vincristine Sulfate Injection is the salt of an alkaloid obtained from a common flowering herb, the periwinkle plant (Vinca rosea Linn). Originally known as leurocristine it has also been referred to as LCR and VCR. The molecular formula for vincristine sulfate is C46H56N4O10 H2SO4. It has a molecular weight of 923.04.
Vincristine sulfate is a white to off-white powder. It is soluble in methanol, freely soluble in water, but only slightly soluble in 95% ethanol. In 98% ethanol, vincristine sulfate has an ultraviolet spectrum with maxima at 221 nm (L+47,100).
Vincristine Sulfate Injection, USP is a sterile, preservative-free, single use only solution available for intravenous use in 2 mL (1 mg and 2 mg) vials. Each mL contains vincristine sulfate, 1 mg; mannitol, 100 mg; and water for injection, q.s. Sulfuric acid or sodium hydroxide have been added for pH control. The pH of Vincristine Sulfate Injection ranges from 4.0 to 5.0. At the time of manufacture, the air in the containers is replaced by nitrogen.
Generic Name: Vincristine Sulfate
Women's Health
Find out what women really need.
Herbal First Aid
Herbal medicine is ancient, but only in recent years have many people started to take notice of its all natural healing powers. See more WebMD Videos »
Oncovin
Health Resources
2008 Election & Health Care on WebMD. Get Informed.
Updated & New
RxList does not provide medical advice, diagnosis or treatment.