Serious ill effects have not been reported following acute ingestion of large doses of other oral contraceptives by young children. Overdosage may cause nausea, and withdrawal bleeding may occur in females. Drospirenone, however, is a spironolactone analogue which has antimineralocorticoid properties. Serum concentration of potassium and sodium, and evidence of metabolic acidosis, should be monitored in cases of overdose.

Non-Contraceptive Health Benefits

The following non-contraceptive health benefits related to the use of oral contraceptives are supported by epidemiological studies which largely utilized oral contraceptive formulations containing doses exceeding 0.035 mg of ethinyl estradiol or 0.05 mg mestranol.

Effects on menses:

•  increased menstrual cycle regularity
•  decreased blood loss and decreased incidence of iron-deficiency anemia
•  decreased incidence of dysmenorrhea Effects related to inhibition of ovulation:
•  decreased incidence of functional ovarian cysts
•  decreased incidence of ectopic pregnancies Effects from long-term use:
•  decreased incidence of fibroadenomas and fibrocystic disease of the breast
•  decreased incidence of acute pelvic inflammatory disease
•  decreased incidence of endometrial cancer
•  decreased incidence of ovarian cancer

YAZ should not be used in women who have the following:

• Renal insufficiency
• Hepatic dysfunction
• Adrenal Insufficiency
• Thrombophlebitis or thromboembolic disorders
• A past history of deep-vein thrombophlebitis or thromboembolic disorders
• Cerebral-vascular or coronary-artery disease (current or history)
• Valvular heart disease with thrombogenic complications
• Severe hypertension
• Diabetes with vascular involvement
• Headaches with focal neurological symptoms
• Major surgery with prolonged immobilization
• Known or suspected carcinoma of the breast
• Carcinoma of the endometrium or other known or suspected estrogen-dependent neoplasia
• Undiagnosed abnormal genital bleeding
• Cholestatic jaundice of pregnancy or jaundice with prior pill use
• Known or suspected pregnancy
• Liver tumor (benign or malignant) or active liver disease
• Heavy smoking (>15 cigarettes per day) and over age 35
• Hypersensitivity to any component of this product

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