DIPROLENE AF Cream contains betamethasone dipropionate, USP, a synthetic adrenocorticosteroid, for dermatologic use in an emollient base. Betamethasone, an analog of prednisolone, has a high degree of corticosteroid activity and a slight degree of mineralocorticoid activity. Betamethasone dipropionate is the 17, 21 -dipropionate ester of betamethasone.

Chemically, betamethasone dipropionate is 9- fluoro-11 p, 17,21- trihydroxy-16p-methylpregna- 1.4. diene- 3,200dione 17,21 -dipropionate, with the empirical formula C₂₈H₂₇FO₇, a molecular weight of 504.6 and the following structual formula.

Betamethasone dipropionate is a white to creamy white, odorless crystalline powder, insoluble in water.

Each gram of DIPROLENE AF Cream 0.05% contains: 0.64 mg betamethasone dipropionate, USP (equivalent to 0.5 mg betamethasone) in an emollient cream base of purified water, chlorocresol, propylene glycol, white petrolatum, white wax, cyclomethicone, sorbitol solution, glyceryl monooleate, ceteareth-30, carbomer 940 and sodium hydroxide R.

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