Acthrel
ACTHREL® (Ferring)
(corticorelin ovine triflutate for injection)
For intravenous injection only
DIAGNOSTIC USE ONLY
DRUG DESCRIPTION
ACTHREL® (corticorelin ovine triflutate for injection) is a sterile, nonpyrogenic, lyophilized white cake powder, containing corticorelin ovine triflutate, a trifluoroacetate salt of a synthetic peptide that is used for the determination of pituitary corticotroph responsiveness. Corticorelin ovine has an amino acid sequence identical to ovine corticotropin-releasing hormone (oCRH). Corticorelin ovine is an analogue of the naturally occurring human CRH (hCRH) peptide. Both peptides are potent stimulators of adrenocorticotropic hormone (ACTH) release from the anterior pituitary. ACTH stimulates cortisol production from the adrenal cortex.
The empirical formula of corticorelin ovine is C 205 H 339 N 59 O 63 S with a molecular weight of 4670.35 Daltons. The structural formula for corticorelin ovine triflutate is described below:
whereas x = 4 - 8.
ACTHREL® for injection is available in vials containing 100 mcg corticorelin ovine (as the trifluoroacetate), 0.88 mg ascorbic acid, 10 mg lactose, and 26 mg cysteine hydrochloride monohydrate. Trace amounts of chloride ion may be present from the manufacturing process. The preparation is intended for intravenous administration.
Generic Name: Corticorelin Ovine
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