Prostin E2
PROSTIN E2®
Manufacturer: Pharmacia & Upjohn
(dinoprostone vaginal suppository)
DRUG DESCRIPTION
PROSTIN E2 Vaginal Suppository, an oxytocic, contains dinoprostone as the naturally occurring prostaglandin E2 (PGE2).
Its chemical name is (5Z,11(alpha),13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1-oic acid. Its chemical structure is:
The molecular formula is C 20 H 32 O 5 . The molecular weight of dinoprostone is 352.5. Dinoprostone occurs as a white crystalline powder. It has a melting point within the range of 64° to 71° C. Dinoprostone is soluble in ethanol and in 25% ethanol in water. It is soluble in water to the extent of 130 mg/100 mL.
Each suppository contains 20 mg of dinoprostone in a mixture of glycerides of fatty acids.
Generic Name: Dinoprostone
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