Find a Drug
Advanced Search

Professional

Tikosyn

Drug Description
font size

TIKOSYN® (Dofetilide Capsules)

To minimize the risk of induced arrhythmia, patients initiated or re-initiated on TIKOSYN should be placed for a minimum of 3 days in a facility that can provide calculations of creatinine clearance, continuous electrocardiographic monitoring, and cardiac resuscitation. For detailed instructions regarding dose selection, see DOSAGE AND ADMINISTRATION. TIKOSYN is available only to hospitals and prescribers who have received appropriate TIKOSYN dosing and treatment initiation education, see DOSAGE AND ADMINISTRATION.

DRUG DESCRIPTION

TIKOSYN (dofetilide) is an antiarrhythmic drug with Class III (cardiac action potential duration prolonging) properties. Its empirical formula is C19H27N3O5S2 and it has a molecular
weight of 441.6. The structural formula is

The chemical name for dofetilide is N-[4-[2- [methyl[2-[4-[ (methylsulfonyl) amino]phenoxy]ethyl] amino]ethyl]phenyl]- methanesulfonamide.

Dofetilide is a white to off-white powder. It is very slightly soluble in water and propan-2-ol and is soluble in 0.1M aqueous sodium hydroxide, acetone and aqueous 0.1M hydrochloric acid.

TIKOSYN capsules contain the following inactive ingredients: microcrystalline cellulose, corn starch, colloidal silicon dioxide and magnesium stearate. TIKOSYN is supplied for oral administration in three dosage strengths: 125 mcg (0.125 mg) orange and white capsules, 250 mcg (0.25 mg) peach capsules, and 500 mcg (0.5 mg) peach and white capsules.

Brand Name: Tikosyn
Generic Name: Dofetilide

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Bookmark this page:



High Blood Pressure Treatment Options

CV Franchilse
CV Franchilse
Individual results may vary
WebMD Symptom Checker - Start Here Ringworm Slideshow: Watch and Learn
WebMD Resources

Health Extras

Test your Health IQ for a chance to win a Wii Fit from WebMD
2008 Election & Health Care on WebMD. Get Informed.

At Risk for Heart Disease?At Risk for Heart Disease?
Thanks to new technology, in just 15 seconds you can tell if you’re at risk for heart disease. Learn about this new tool. See more WebMD Videos »