Fudr
Sterile
FUDR
(brand of floxuridine)
FOR INTRA-ARTERIAL INFUSION ONLY
Rxonly
DRUG DESCRIPTION
WARNINGIt is recommended that FUDR be given only by or under the supervision of a qualified physician who is experienced in cancer chemotherapy and intra-arterial drug therapy and is well versed in the use of potent antimetabolites. Because of the possibility of severe toxic reactions, all patients should be hospitalized for initiation of the first course of therapy. |
Sterile FUDR (floxuridine), an antineoplastic antimetabolite, is available as a sterile, nonpyrogenic, lyophilized powder for reconstitution. Each vial contains 500 mg of floxuridine which is to be reconstituted with 5 mL of sterile water for injection. An appropriate amount of reconstituted solution is then diluted with a parenteral solution for intra-arterial infusion (see DOSAGE AND ADMINISTRATION).
Floxuridine is a fluorinated pyrimidine. Chemically, floxuridine is 2'-deoxy-5-fluorouridine with an empirical formula of C 9 H 11 FN 2 O 5 . It is a white to off-white odorless solid which is freely soluble in water.
The 2% aqueous solution has a pH of between 4.0 to 5.5. The molecular weight of floxuridine is 246.19 and the structural formula is:
Generic Name: Floxuridine
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