Ifex

Drug Description

font size

IFEX®
(ifosfamide for injection)

DRUG DESCRIPTION

WARNING

IFEX® should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents. Urotoxic side effects, especially hemorrhagic cystitis, as well as CNS toxicities such as confusion and coma have been associated with the use of IFEX. When they occur, they may require cessation of IFEX therapy. Severe myelosuppression has been reported. (See ADVERSE REACTIONS section.)

IFEX® (ifosfamide for injection) single-dose vials for constitution and administration by intravenous infusion each contain 1 gram or 3 grams of sterile ifosfamide. Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. Ifosfamide is 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide. The molecular formula is C ₇H ₁₅Cl ₂N ₂O ₂P and its molecular weight is 261.1. Its structural formula is: