Leukeran

Drug Description

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LEUKERAN®
(chlorambucil)
Tablets

WARNING
LEUKERAN (chlorambucil) can severely suppress bone marrow function. Chlorambucil is a carcinogen in humans. Chlorambucil is probably mutagenic and teratogenic in humans. Chlorambucil produces human infertility (see WARNINGS and PRECAUTIONS).

DRUG DESCRIPTION

LEUKERAN (chlorambucil) was first synthesized by Everett et al. It is a bifunctional alkylating agent of the nitrogen mustard type that has been found active against selected human neoplastic diseases. Chlorambucil is known chemically as 4-[bis(2chlorethyl)amino]benzenebutanoic acid and has the following structural formula:

Chlorambucil hydrolyzes in water and has a pKa of 5.8.

LEUKERAN (chlorambucil) is available in tablet form for oral administration. Each sugar-coated tablet contains 2 mg chlorambucil and the inactive ingredients acacia, corn and wheat starch, lactose, magnesium stearate, pharmaceutical glaze, polysorbate 60, sucrose, and talc. Printed with edible black ink.

Brand Name: Leukeran
Generic Name: Chlorambucil

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